Bariatric Surgery information
Ghrelin Levels After Gastric Bypass Surgery

Review of Serum Ghrelin Levels in Response to Glucose Load in Obese Patients After Stomach Bypass

Bariatric Surgery - Bariatric Research Studies

Serum ghrelin levels in response to glucose load in obese subjects post-gastric bypass surgery

We sought to elucidate further the mechanisms leading to weight loss after gastric bypass (GBP) surgery in morbidly obese individuals. Ghrelin is a gastroenteric appetite-stimulating peptide hormone, fasting levels of which decrease with increasing adiposity and increase with diet-induced weight loss. In addition, ghrelin levels rapidly decline postprandially.

Method

We measured serum ghrelin responses to a 75-g oral glucose tolerance test (OGTT) in 6 subjects who had undergone gastric bypass surgery 1.5 +/- 0.7 years before testing and compared these responses with 6 obese subjects about to undergo gastric bypass surgery, 6 obese nonsurgical subjects (matched for BMI to the post-GBP surgical group), and 5 lean subjects.

Results

Despite weight loss induced by the gastric bypass surgery, fasting serum ghrelin levels were significantly lower in the post-gastric bypass surgery group than in the lean subject (by 57%) or pre-gastric bypass surgery (by 45%) group. Serum ghrelin levels during the OGTT were significantly lower in postoperative than in lean, obese pre-gastric bypass surgical, or obese nonsurgical subjects. The magnitude of the decline in serum ghrelin levels between 0 and 120 minutes post-OGTT was significantly smaller in postoperative (by 62%), obese pre-gastric bypass surgical (by 80%), or obese nonsurgical (by 69%) subjects in comparison with lean subjects.

Discussion

Serum ghrelin levels in response to OGTT are lower in subjects post-gastric bypass surgery than in either lean or obese subjects. Tonically low serum ghrelin levels may be involved in the mechanisms inducing sustained weight loss after gastric bypass surgery.

Source:
Tritos NA, Mun E, Bertkau A, Grayson R, Maratos-Flier E, Goldfine A. Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA.
National Library of Medicine 2003

Bariatric Surgery
Adjustable Gastric Banding UK - After Lap-Band Surgery - Band Repositioning Slippage - Long Term Effects Gastric Banding - BAROS) Laparoscopic Gastric Banding - Lap-Band Weight Loss Surgery Effects - Esophagogastric Banding - Gastric Banding Grade 3 Obesity - Gastric Banding Older Obese Patients - Laparoscopic Adjustable Gastric Banding UK - Gastroplasty Conversion - Homocysteine Levels Folate B12 - Laparoscopic Adjustable Gastric Banding Morbid Obesity - Laparoscopic Adjustable Band - Laparoscopic Gastric Banding Side Effects - Laparoscopic Banding Surgical Technique - Laparoscopic Lap-Band Outcomes - Laparoscopic Gastric Lap-Band Trial - Laparoscopic Silicone Gastric Banding Operation - Radiological Imaging After Banding - Revision of Failed Gastric Bariatric Operations - Silicone Gastric Banding Failure Rate - Visceral Subcutaneous Fat - Dietary Changes After Gastroplasty - Duodenal Switch Dyslipoproteinemia - Gastroplasty Eating Behavior - Gastrointestinal Quality of Life - Hand Assisted Laparoscope VGB - Laparoscopic Gastroplasty - Laparoscopic Stapling - Vertical Banded Gastroplasty Results - Mason-MacLean Gastroplasty - Non-Adjustable Silicone Ring - Open Versus Laparoscopic Gastroplasty - Patient Compliance Gastroplasty - Peptide YY After Gastroplasty - Personality Profiles Obese Patients - Pre-Operative Resting Weight Loss - Weight Loss After Gastroplasty - Back Pain After Gastroplasty - Bariatric Follow-up Outcomes - Binge Eating Disorder Bariatrics - Bone Mass After Gastric Bypass - Bone Metabolism Gastroplasty - Gastric Bypass Venous Stasis - Gastric Surgery Insulin Effects - Weight Loss Surgery Sleep Apnea - Weight Loss Surgery Free Radical Antioxidants - Gastroplasty Diabetes Dyslipidemia - Insulin Tolerance in Bariatric Surgery Patients - Laparoscopic Gastroplasty Study - Nutritional Complications Gastric Bypass - Obesity-Associated Disorders - Orthostatic Hypotension - Gastric Bypass Health Improvements - Predictors of Complication after Roux-en-Y Bypass - Pseudo-Achalasia Gastric Banding - Gastric Acid Secretion Reduction in Bariatric Surgery - Roux-en-Y Gastric Bypass Evaluation - Predicting Success After Roux-en-Y - Psychiatric Diagnosis Gastric Surgery - Psychopathological Status After Weight Loss - Psychosocial Factors Weight Loss After Bariatric Surgery - Quality of Life After Weight Loss Surgery - Socio-economic Characteristics Obesity Surgery - Large Volume Liposuction Effects - Weight Loss Surgery Reoperations - Laparoscopic Reoperative Surgery - Weight Loss After Gastric Surgery - Pregnancy after Gastric Banding - Pregnancy after Lap-Band Surgery - Weight Loss Co-Morbid Conditions - Weight Loss After Bariatric Surgery

BARIATRIC & GASTRIC SURGERY INFORMATION

What Is Weight Loss Surgery | Gastric Surgery - How to Qualify | Types Of Weight Loss Surgery | How Bariatric Surgery Works | Laparoscopy | How Effective Is Surgery | Success Rates | Health Benefits | Complications | Weight Loss Surgery Costs | Find Weight Loss Surgeon | Support Groups | Malabsorption | Gastric Bypass | Biliopancreatic Diversion Bypass | Biliopancreatic Details | Biliopancreatic Benefits/ Biliopancreatic Risks | Duodenal Switch Bypass | Duodenal Switch Details | Duodenal Switch Benefits/ Duodenal Switch Risks | Roux-en-Y Bypass Laparoscopic | Roux-en-Y Bypass Open Surgery | Roux-en-Y Gastric Bypass Benefits/ Gastric Bypass Risks | Roux-en-Y Details | Fobi Pouch Gastric Bypass | Fobi Pouch Benefits/ Fobi Pouch Risks | Dumping Syndrome | How Dumping Occurs | Bypass Health Dangers | Diet After Gastric Bypass | Restrictive Procedures | Gastric Banding | Adjustable Gastric Banding | Lap Band Procedure | Lap Band Details | Lap Band Risks & Benefits | Silastic Gastric Ring Surgery | Gastroplasty | Vertical Banded Gastroplasty | Gastric Surgery | Gastric Stapling | Stomach Stapling | Benefits of Gastric Stapling | Obesity Condition | Obesity Mortality Rate | Obesity Health Risks | Obesity Surgical Treatment | Surgery For Morbid Obesity | Weight-Related Health Risks | Obesity Surgery Research | Bariatric Studies | Gastric Reduction Articles | Weight Loss Surgery Statistics | Stomach Bypass | Stomach Banding | Stomach Gastroplasty | Laparoscopy | Weight Loss Surgery Health Complications | Nutrition after Bypass | Weight Loss Surgery Psychosocial Factors | Gastric Reduction Surgery | Weight Loss Surgery Clinics | Plastic Surgery | Plastic Surgery After Weight Loss | Tummy Tuck/Abdominoplasty | Dermolipectomy | Body Lift | Gynecomastia Enlarged Male Breast | Panniculectomy | Thigh Lift | Cost of Plastic Surgery | Plastic Surgery Information | Cosmetic Surgery | Lipoplasty | Liposuction Types | Health Risks of Liposuction | Tumescent Method | Liposuction Butt | Liposuction Inner Thighs | Liposuction Front Thighs | Cost of Liposuction | Information About Lipoplasty


Laparoscopic or open bariatric surgery, such as gastric banding or bypass is not an easy solution to morbid obesity and weight loss. It is a serious surgical procedure, involving health risks. To produce lasting weight loss it requires a long-term patient commitment to eating a healthy diet and following a regular program of physical exercise. Life-long use of nutritional supplements may also be necessary. So, before deciding, discuss your options fully with your doctor. © 2003-2017 Bariatric-Surgery.Info - Terms - Contact - Information - Resources