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Articaine Hydrochloride Local Anesthesia in Tumescent Liposuction

Pharmacokinetic Characteristics and Safety of Articaine HCl Analgesia

Guide to Weight Loss Surgery - Research Into Gastric Reduction Surgery

Articaine Hydrochloride Local Anesthesia in Tumescent Liposuction

The aim of the investigation was to assess the pharmacokinetic characteristics and safety of articaine HCl used in tumescent local anesthesia for liposuction. Maximum plasma concentrations of articaine HCl were observed from 136 to 264 ng/mL, on average, from 1.2 to 4.3 hours after the start of infiltration, depending on the area of liposuction. The average extent of absorption ranged from 827 to 2203 ng*h/mL. Average maximum plasma concentrations of articainic acid ranged from 1719 to 7292 ng/mL.

Results

The high articainic acid concentrations at 1 hour after the start of infiltration indicate that articaine HCl was hydrolyzed rapidly by esterases in tissue and plasma. Although up to 38.2 mg/kg body weight articaine HCl was applied, no cardiac side effects or symptoms of central nervous intoxication occurred.

Conclusion

Articaine HCl provided a safe and sufficient analgesia for tumescent liposuction.

Source:
Grossmann M, Sattler G, Pistner H, Oertel R, Richter K, Schinzel S, Jacobs LD. Institut fur Klinische Pharmakologie Bobenheim, Prof Dr Lucker GmbH (IKP GmbH), Grunstadt, Germany.

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Laparoscopic or open bariatric surgery, such as gastric banding or bypass is not an easy solution to morbid obesity and weight loss. It is a serious surgical procedure, involving health risks. To produce lasting weight loss it requires a long-term patient commitment to eating a healthy diet and following a regular program of physical exercise. Life-long use of nutritional supplements may also be necessary. So, before deciding, discuss your options fully with your doctor. © 2003-2017 Bariatric-Surgery.Info - Terms - Contact - Information - Resources